HMR4005
Darusentan
CAS: 171714-84-4
Molecular Formula: C22H22N2O6
HMR4005 - Names and Identifiers
HMR4005 - Physico-chemical Properties
| Molecular Formula | C22H22N2O6 |
| Molar Mass | 410.42 |
| Density | 1.268±0.06 g/cm3(Predicted) |
| Boling Point | 587.3±60.0 °C(Predicted) |
| pKa | 1.82±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | Darusentan ((S)-Darusentan) competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K i =13 nM. In isolated endothelium-denuded rat aortic rings, Darusentan inhibits endothelin-induced vascular contractility with a pA 2 =8.1±0.14. Darusentan ( 0.001-1μM) inhibits ET-1-induced signaling in cultured RAVSMs. |
HMR4005 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.437 ml | 12.183 ml | 24.365 ml |
| 5 mM | 0.487 ml | 2.437 ml | 4.873 ml |
| 10 mM | 0.244 ml | 1.218 ml | 2.437 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.487 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Darusentan Visit Supplier Webpage Request for quotationCAS: 171714-84-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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